Characterization of Silver Doped Hydroxyapatite Prepared by EDTA Chelate Decomposition Method

Abstract

ABSTRACTIn this study, Ag doped hydroxyapatite (HA) samples prepared by EDTA chelate decomposition method were characterized with X-Ray Diffraction Spectroscopy (XRD), Scanning Electron Microscopy (SEM) and antimicrobial sensitivity test. Hydroxyapatite (Ca10(PO)6(OH)2) and NaCaPO4 (rhenanite) phases were observed while Ag was present in the form of Ag2O. Results showed that microstructurally controlled HA-based composites with NaCaPO4 interphase can be prepared, which significantly enhances sinterability of hydroxyapatite at 1100° C without formation of any undesired second phases, such as tricalcium phosphate (TCP) known to decrease the stability of HA. The antibacterial sensitivity was tested with E.Coli gram-negative bacteria. The radius of circle enclosing the sample increases with increasing Ag content in the structure as an indication of the region of non-bacterial activity.