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Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice

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dc.contributor.authorChen, Yihan
dc.contributor.authorWu, Weihao
dc.contributor.authorNi, Xiaoyu
dc.contributor.authorFarag, Mohamed A.
dc.contributor.authorCapanoglu, Esra
dc.contributor.authorZhao, Chao
dc.date.accessioned2026-01-25T23:49:13Z
dc.date.issued2022-01-01
dc.description.abstractType 2 diabetes (T2D) has emerged as one of the most acute public health diseases of the present time, which increases with the population ageing. This study aimed to evaluate the hypoglycaemic activity of Ulva lactuca oligosaccharide (ULO) under ageing-related diabetes conditions in an animal model. The results demonstrated that ULO can promote hypoglycaemia and delay senescence as mediated via GLP-1/GLP-1R pathway to mobilize the intercommunication between the brain and gut. In addition, twenty-six different metabolites and eight different bacteria were screened in the brain and the gut, respectively. A network relationship displayed that all-trans-retinoic acid has positive relationships with Bifidobacterium and Streptococcus, suggesting that plays a potential key role in maintaining the hypoglycaemic and anti-ageing activities of ULO. Based on these findings, ULO might be an efficient therapy for restoring blood glucose metabolism and delaying brain senescence in elderly T2D patients.
dc.description.urihttps://doi.org/10.1016/j.crfs.2022.07.003
dc.description.urihttps://pubmed.ncbi.nlm.nih.gov/35865803
dc.description.urihttp://dx.doi.org/10.1016/j.crfs.2022.07.003
dc.description.urihttps://doaj.org/article/2c08182e4f6049b88e05c5b9475fb585
dc.identifier.doi10.1016/j.crfs.2022.07.003
dc.identifier.endpage1139
dc.identifier.issn2665-9271
dc.identifier.openairedoi_dedup___::a5dd76fe4236ab8e56fe38d276ebde64
dc.identifier.orcid0000-0002-2124-4544
dc.identifier.orcid0000-0003-1096-632x
dc.identifier.startpage1127
dc.identifier.urihttps://hdl.handle.net/11527/53207
dc.identifier.volume5
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofCurrent Research in Food Science
dc.rightsOPEN
dc.sdg.typeGoal 3: Good Health and Well-being
dc.subjectDifferential metabolite
dc.subjectNutrition. Foods and food supply
dc.subjectUlva lactuca oligosaccharide
dc.subjectArticles from the special issue: 6th International Symposium on Phytochemicals in Medicine and Food, edited by Jianbo Xiao, Jinping Si and Huifan Liu
dc.subjectType 2 diabetes
dc.subjectGut microbiota
dc.subjectTP368-456
dc.subjectSenescence
dc.subjectFood processing and manufacture
dc.subjectTX341-641
dc.titleRegulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice
dc.typeArticle
dspace.entity.typePublication

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