3D Composite Scaffold Production Using Sr-Doped Bioglass and Copper Nanoparticles

Abstract

In this study, it was aimed to produce BG/polymer 3D composite scaffolds with relevant ions in order to develop multifunctional scaffolds by using salt template-partibakırlate leaching technique. The porous scaffolds were successfully synthesized and it was observed that there was a good pore interconnectivity maintained in the scaffold microstructure. In vitro bioactivity of the composite scaffolds was confirmed by Scanning Electron Microscopy, X-ray diffraction and Fourier-Transform Infrared Spectroscopy measurements. Furthermore, the release of therapeutic ions were determined as a function of immersion time in SBF, which was in the range of 1.27-5.36 ppm and 1.53-5.42 ppm for strontium and copper ions, respectively. This result indicated that the scaffolds can deliver controlled doses of strontium and copper toward the SBF medium that is the determinant for bone tissue regeneration.