Kimya Bölümü

Bu koleksiyon için kalıcı URI

http://hdl.handle.net/11527/25345

Gözat

Yazar "Aydoğan, Abdullah" ile Kimya Bölümü'a göz atma
  • Öge
    Drug encapsulation and release with a nonionic amphiphilic calix[4]pyrrole
    (Royal Society of Chemistry, 2024) Mirabolghasemi, Mana ; Bektaş, Necla ; Sancaklı, Buse ; Dağ, Aydın ; Aydoğan, Abdullah ; https://orcid.org/0000-0001-6377-5143 ; Kimya Bölümü
    A polyethylene glycol-tethered amphiphilic calix[4]pyrrole compound (C4P-PEG) was synthesized via an esterification reaction between the corresponding alcohol-functionalised calix[4]pyrrole and carboxylic acid ended polyethylene glycol. The structure of C4P-PEG was confirmed by means of NMR spectroscopy and high-resolution mass spectrometry. The complexation ability of the control compound octamethylcalix[4]pyrrole and C4P-PEG with chemotherapeutic cancer drug, doxorubicin-HCl, was shown with the aid of various NMR techniques in DMSO, containing 1.5% (wt) water. Nonionic amphiphilic calix[4]pyrrole compound C4P-PEG was then shown to produce stable micelles in water. The title compound was also used to encapsulate doxorubicin-HCl in aqueous medium and its concurrent drug release ability was illustrated under acidic and basic conditions. While the characterizations of drug-free and drug-loaded micelles were carried out with dynamic light scattering experiments and transmission electron microscopy, the drug loading capacity, encapsulation efficiency and in vitro drug release profiles were studied with the aid of UV-vis spectrophotometry.
  • Öge
    Supramolecular alternating polymers based on calix[4]pyrrole and pillar[5]arene molecular recognition
    (American Chemical Society, 2024) Memiş, Deniz ; Bektaş, Necla ; Aydoğan, Abdullah ; 0000-0002-0506-6020 ; 0000-0002-8944-3267 ; 0000-0001-6377-5143 ; Kimya Bölümü
    Supramolecular alternating polymers (SAPs) were constructed based on orthogonal interactions between an alkylnitrile-tethered calix[4]pyrrole and two different carboxylate-functionalized pillar[5]arene monomers possessing different chain lengths. Concurrent anion complexation and host–guest interactions were utilized by means of calix[4]pyrrole- and pillar[5]arene-based molecular recognitions. Characterization and multiresponsive behaviors of the resulting SAPs were characterized by means of a series of analyses, including various nuclear magnetic resonance techniques, viscosity measurements, and scanning electron microscopy. The resulting polymers were also applied to the fabrication of hierarchical materials with different dimensionalities. These materials include spherical aggregates with zero-dimensionality, fibers with one-dimensionality, two-dimensional microporous films, and finally three-dimensional materials. Current work represents the first example of SAPs based on calix[4]pyrrole and pillar[5]arene molecular recognition and is expected to be useful for designing and preparation of advanced, multicomponent synthetic self-assembled systems.