Kimya Mühendisliği

Bu koleksiyon için kalıcı URI

http://hdl.handle.net/11527/18124

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Yazar "Batirel, Saime" ile Kimya Mühendisliği'a göz atma
  • Öge
    Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications
    (Springer, 2024) Kocaağa, Banu ; Bağımsız, Gamze ; Alev, İbrahim Avni ; Miavaghi, Mehran Aliari ; Sirkecioğlu, Ahmet ; Batirel, Saime ; Güner, Fatma Seniha ; Kimya Mühendisliği
    The development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by pH changes. These films are composed of MIL-101(Fe) particles and pectin polymers. MIL-101(Fe) was chosen for its high surface area, stability in aqueous environments, and biocompatibility, ensuring low toxicity to normal cells. MIL-101(Fe)-embedded-pectin hydrogels were synthesized and characterized using Fourier-transformed infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometry, particle size analysis, and goniometry. Rheological analysis assessed the hydrogels’ viscoelastic behavior, and UV-spectrophotometry was utilized for drug loading and release studies. The hydrogels exhibited shear-thinning properties, enhancing shape adaptability and recovery, crucial for wound-dressing applications. Controlled drug release was achieved by maintaining the PC solution’s pH between 8.2 and 9.8 during the drug-loading step. The hydrogel film’s impact on wound healing was evaluated through an in vitro wound healing assay, and cytotoxicity was assessed using a WST-1 cell proliferation assay with human dermal fibroblast cells. Results demonstrated that pectin composites enhance cell viability and support fibroblast cell migration without adverse effects, indicating their potential for effective wound healing applications. This study highlights the potential of MIL-101(Fe)-embedded-pectin hydrogels in advancing wound care technology.
  • Öge
    Non-covalent functionalization of magnetic carbon nanotubes with Fmoc amino acid-modified polyethylene glycol
    (Wiley, 2024) Murat, Fusun Sevval ; Güner Yılmaz, Özde Zeynep ; Bozoglu, Serdar ; Batirel, Saime ; Baysak-Käseberg, Elif ; Hizal, Gurkan ; Karatepe, Nilgün ; Güner, Fatma Seniha ; orcid.org/0000-0002-3414-4868 ; Kimya Mühendisliği
    Once dispersion and cytotoxicity issues are resolved, it has been proven that carbon nanotubes (CNTs) have great advantages in biomedical applications due to their unique properties. In this study, the superiority of carbon nanotubes was combined with magnetic targeting strategies, and a solution to the distribution problem in the aqueous media of the resulting CNTs decorated with iron oxide (mCNTs) was sought. A non-covalent functionalization approach has been utilized to overcome this fundamental drawback of mCNTs. Conjugates of polyethylene glycol monomethyl ether and 9- fluorenyl methyl chloroformate (Fmoc) amino acids were used to coat the lateral surfaces of mCNTs, making them more water-soluble. The selected Fmoc amino acids have different numbers of aromatic rings, which is known to affect the coating efficiency in non-covalent functionalization and therefore, the dispersion behavior of the CNTs. Their coating yields, dispersion behaviors, magnetism, charge, and size properties have been determined. All coated mCNT samples displayed superparamagnetic behavior. Dispersion tests showed a promise to increase the stability of mCNTs with this approach. Moreover, we demonstrated that the functionalization of mCNTs affects cell viability in a dose-dependent manner. The main finding of this study is that mCNTs can be successfully functionalized with Fmoc amino acid-modified polyethylene glycol.
  • Öge
    Plasma treated-double layer electrospun fiber mats from thermoplastic polyurethane and gelatin for wound healing applications
    (Wiley, 2024) Yıldırım, Arzu ; Erdoğan, Eray Sarper ; Çağlayan, Şeyma ; Keskinkaya, Rüya ; Türker, Yurdanur ; Karbancıoğlu-Güler, Funda ; Dikmetaş, Dilara Nur ; Batirel, Saime ; Erol Taygun, Melek ; Guner, F. Seniha ; orcid.org/0000-0002-3414-4868 ; Kimya Mühendisliği
    Conventional wound treatment options provide a barrier against exogenous microbial penetration but cannot simultaneously provide an antibacterial characteristic and promote healing. However, bioactive dressings can accelerate wound healing and have an antibacterial effect in addition to being able to cover and protect lesions. In this study, double-layer thermoplastic polyurethane (TPU)-gelatin fibrous dressings that mimic the epidermis and dermis layers of the skin were fabricated via electrospinning technique. As a bioactive agent, Hypericum perforatum oil (HPO) was utilized to impart antibacterial and therapeutic properties to the dressings. Tannic acid was also used in fiber mat formulations as a cross-linking agent. Oxygen plasma treatment was applied as a surface activation technique to improve adhesion of TPU and gelation layers. The fiber structure of the mats was revealed by a scanning electron microscopy (SEM) study. Fourier transform infrared (FTIR) spectroscopy was used to demonstrate HPO loading onto the mats. The water vapor transmission rate (WVTR) and fluid absorbency of the mats were compared with some commercial dressings. According to these results, it can be suggested that the mats can be used for moderate to high exudative wounds. All dressings, even the control sample showed antibacterial features against both Staphylococcus aureus and Escherichia coli bacteria due to the tannic acid. In vitro wound healing assays were carried out on the plasma-treated sample and it was observed that the sample did not negatively affect the migration and proliferation abilities of the cells which are necessary for wound healing. Overall results indicated that the plasma-treated fibrous mat would be a good candidate as a wound dressing material having an antibacterial character.