The preparation and biomedical applications of self-assembled two-dimensional sandalose gum supported polyvinyl alcohol/alginate bio-polymeric nanoparticles

Abstract

In this study, green self-assembled two-dimensional (2D) bio-preservatives were prepared for the sonosynthesis of sandalose gum-supported bio-polymeric nanoparticles (PNPs) with excellent biological activities. Polyvinyl alcohol (PVA), alginate (Alg), and sandalose gum (SG) were used to fabricate the green and low-cost bio-preservative. The prepared PVA/Alg/SG PNPs were confirmed using various characterization techniques such as SEM, HRTEM, XRD, FTIR, DLS, zeta potential, TGA, and DSC. According to the surface characterization results, the green self-assembled 2D PVA/Alg/SG PNPs had a spherical shape and particle diameters ranging from 10-50 nm. The thermal results showed that PVA/Alg/SG PNPs had good thermal stability. Furthermore, we investigated the antibacterial and antifungal activities of the self-assembled 2D PVA/Alg/SG PNPs as a safe bio-preservative against pathogenic microorganisms for use in biomedical applications. Consequently, our experimental results indicated a strong synergistic interaction between pathogenic microorganisms and the surface of the 2D nanostructure, resulting in the preservative efficacy of PNPs with a high performance.