Publication: The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations
Loading...
Date
Authors
Advisor
Department
Journal Title
Journal ISSN
Volume Title
Publisher
Informa UK Limited
Type
Abstract
This paper aims to correlate Alzheimer's disease (AD) related striatal pathologic changes with the fractional amplitude of low-frequency fluctuations (fALLF) in the blood oxygenation level-dependent (BOLD) signal in the resting state functional Magnetic Resonance Imaging (rs-fMRI). A dopamine modulated Izikhevich neuron model based network of striatum region is constructed. Balloon-Windkessel hemodynamic model is used to obtain BOLD signals. fALFF differences between two frequency bands (slow-5:0.01-0.027 Hz; slow-4:0.027-0.073 Hz) are investigated in the case of dopamine depletion, decrease in the synaptic connectivity and the input from cortical and thalamic region, assumed that they are the degenerations occurring in AD.
Description
Journal or Series
Computer Methods in Biomechanics and Biomedical Engineering
ISSN
1025-5842
ISBN
Rights
OPEN
Keywords
Male, Neurons, Dopamine, Hemodynamics, Signal Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Biological, Neostriatum, Oxygen, Alzheimer Disease, Synapses, Humans, Computer Simulation, Female