ANALYSIS OF THE EFFECT OF PHYSICAL PROPERTIES OF DRUG CO-CRYSTALS ON DISSOLUTION CONCENTRATION

Abstract

Psoriasis is an itchy and non-contagious skin disease. Its treatment method varies according to the severity of the disease. In oral treatments used in heavy stages, dissolution behavior is a vital characterization parameter for evaluating cocrystal, understanding dissolution mechanism, and predicting bioavailability of the drug. In this study, dissolution of cocrystals used in psoriasis was investigated. Effect of (i) different shapes, (ii) sizes, and (iii) grinding of cocrystals on the dissolution were considered with ultraviolet-visible (UV/Vis) spectroscopy. Results show that different physical properties and grinding can significantly increase the dissolution of cocrystals.